Protocol scheme of JGOG 2043 for adjuvant chemotherapy for endometrial cancer. Patients eligibility: Patients who received surgical staging laparotomy, and pathologically confirmed endometrial cancer under the following conditions. 1) FIGO stage Ic to II, with grade 2 or 3 tumor (G3 included serous, clear, undifferentiated tumor). 2) FIGO stage III and IV tumor without distant metastasis. 3) age 20 to 75 years old, performance status 0-2, reasonable organ function.