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. Author manuscript; available in PMC: 2009 Jul 3.
Published in final edited form as: Expert Rev Anticancer Ther. 2009 May;9(5):597–612. doi: 10.1586/era.09.22

Figure 1. Three models on the origins of CNS malignancies.

Figure 1

(A) Normal adult NSCs are recruited to the site of tumor and help to regenerate tumor stromal cells. (B) NSCs undergo malignant transformation into a brain tumor stem cell. (C) Fully committed adult brain cells accumulate mutations over time to transform into brain tumor stem cells.

NSC: Neural stem cell.