Box 1.
Summary of neural stem cell therapies for gliomas.
| Chemotherapeutic vehicles | |
| • Cytosine deaminase | [23,110] |
| • HSV-thymidine kinase | [109,112] |
| • Deoxycytosine kinase (not yet used in NSCs) | [113] |
| • Carboxylesterase (not yet used in NSCs) | [114-116] |
| Viral delivery vehicles | |
| • Replication-conditional HSV-1 vectors | [111] |
| • Conditionally replicating adenovirus | [118,119] |
| Immunotherapeutic vehicles | |
| • IL-4 | [120,121] |
| • IL-12 | [122] |
| • IL-23 | [123] |
| • TRAIL | [127-132] |
| • IFN-β | [137] |
| Inhibition of glioma migration | |
| • PEX | [140] |
HSV: Herpes simplex virus; NSC: Neural stem cell; PEX: Hemopexin-like domain of MMP-2; TRAIL: TNF-related apoptosis-inducing ligand