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. 2009 Jul 21;7(7):e1000157. doi: 10.1371/journal.pbio.1000157

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Supekar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Children had significantly greater subcortical-primary sensory, subcortical-association, subcortical-paralimbic, and lower paralimbic-association, paralimbic-limbic, association-limbic connectivity than young-adults (p<0.01, indicated by **). Error bars represent standard error. (B) Graphical representation of developmental changes in functional connectivity along the posterior-anterior and ventral-dorsal axes, highlighting higher subcortical connectivity (subcortical nodes are shown in green) and lower paralimbic connectivity (paralimbic nodes are shown in gold) in children, compared to young-adults. Brain regions are plotted using the y and z coordinates of their centroids (in mm) in the MNI space. 430 pairs of anatomical regions showed significantly higher correlations in children and 321 pairs showed significantly higher correlations in young-adults (p<0.005, FDR corrected). For illustration purposes, the plot shows differential connectivity that were most significant, 105 pairs higher in children (indicated in red) and 53 higher in young-adults (indicated in blue), (p<0.0001, FDR corrected).