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. Author manuscript; available in PMC: 2009 Jul 3.
Published in final edited form as: J Hepatol. 2006 Oct 6;46(2):222–229. doi: 10.1016/j.jhep.2006.08.012

Figure 3.

Figure 3

Tannic acid (TA) allows dose reduction when combined with 5-fluorouracil (5FU) or mitomycin C (MMC). The dose-reduction effect is a measure of how much the dose of each drug in a synergistic combination may be reduced at a given effect level compared with the doses of each drug alone. The dose-reduction index was calculated for MMC and 5FU using the mean values of the proliferative index of four separate studies for Mz-ChA-1 cells. When TA is combined with either agent, there is a marked dose reduction possible, which is greater for MMC than for 5FU (grey bars). The use of gemcitabine (GEM) in combination with MMC allows a much lower dose-reduction for MMC, but a comparable reduction in 5FU dose compared to the combination of tannic acid with these agents (white bars).