Figure 4. The effect of BMI increase on plasma lipidome.

Changes in plasma lipidome of men with BMI >27.5 kg/m² (n = 28) relative to a control group of men with BMI≤27.5 kg/m² (n = 42), as determined by clinical indices (panel A) and by top-down shotgun mass spectrometry (panel B). In B relative % was determined for each species individually, irrespective of its absolute abundance. In the diagram, within each lipid class, species were sorted according to their absolute abundance from top to bottom in descending order. For example, among the TAG class the species TAG [52∶2] was the most abundant, while TAG [49∶2] was the least abundant. Data are presented as mean. Statistical analysis was performed by univariate analysis of variance.