Figure 7.

Abnormal accumulation of interneurons in LI and SPP in Cdk5^−/− and reeler mice, respectively. E18.5 coronal sections, of Cdk5^−/− and reeler forebrain, stained with Nissl and labeled with antibodies against CB and LHX6. In the Cdk5^−/− cortex, LI is wide and cell dense (A) and packed with numerous CB⁺ (B) and LHX6⁺ (C) cells. In reeler mice, SPP, containing undivided (or mixed) LI and SP cells, is a thick cortical layer (D) containing an abundance of CB⁺ (E) and LHX6⁺ (F) cells. Dashed lines represent the border between LI or SPP and the rest of the developing cortical layers. Scale bar, 100 μm.