Table 3.
Effect of surgical interventions on serum bile acids and conjugates in CD cohorts (nmol/L)
BA class | BA/BA-conjugate | Control | No surgery | Ileocecal resection | Colectomy | Other surgery | Ileocecal resection + other surgery |
Primary | CA | 62.5 | 52.0 | 160.0ab | 71.0 | 57.5c | 89.0b |
TCA | 23.6 | 0.0a | 0.0ab | 9.5c | 8.0c | 0.0 | |
GCA | 383.5 | 240.5a | 156.0ab | 375.0c | 212.0 | 221.5a | |
CDCA | 196.5 | 144.0a | 505.0ab | 174.5 | 153.0 | 121.0 | |
TCDCA | 230.5 | 81.0a | 19.0ab | 37.5ab | 55.5a | 17.0ab | |
GCDCA | 1446.0 | 848.5a | 767.0a | 1059.0 | 663.5a | 772.0 | |
Secondary | DCA | 239.8 | 90.5a | 11.0a | 6.5ab | 17.5a | 53.0d |
TDCA | 48.2 | 5.9a | 0.0ab | 0.0a | 0.0ab | 0.0a | |
GDCA | 238.6 | 64.0a | 0.0ab | 0.0ab | 0.0ab | 43.5a | |
LCA | 15.0 | 7.0a | 5.9a | 3.0a | 4.7a | 2.9a | |
TLCA | 0.0 | 0.0 | 0.0ab | 0.0ab | 0.0 | 0.0 | |
GLCA1 | 17.4 | 3.6a | 0.0a | 0.0 | 2.3 | 0.0 | |
UDCA | 28.5 | 14.5a | 26.0b | 12.7 | 53.5 | 22.5 | |
TUDCA | 0.0 | 0.0 | 0.0a | 0.0a | 0.0a | 0.0a | |
GUDCA1 | 137.9 | 95.2a | 59.7 | 92.1 | 323.5 | 75.6 | |
Tertiary | HDCA | 0.0 | 27.0a | 10.0a | 9.5a | 9.0a | 2.0a |
THDCA | 0.0 | 0.0a | 0.0 | 0.0 | 0.0 | 0.0 | |
GHDCA1 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 |
Control: n = 310; No surgery: n = 64, n = 311; Ileocecal resection: n = 41, n = 161; Colectomy: n = 22, n = 81; Other surgery: n = 12, n = 41; Ileocecal resection + other surgery: n = 12, n = 91. Data expressed as medians.
P < 0.05 vs control,
P < 0.05 vs no surgery,
P < 0.05 vs ileocecal resection,
P < 0.05 vs colectomy (Mann-Whitney U test).