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. Author manuscript; available in PMC: 2009 Jul 4.

Published in final edited form as: J Urol. 2008 Mar 18;179(5):1850–1856. doi: 10.1016/j.juro.2008.01.047

Bladder biopsies were stained with anti-HB-EGF primary antibody followed by a standard streptavidin method. HB-EGF staining was graded semiquantitatively from 0 (none) to 3 (intense). On each biopsy the urothelium and lamina propria were graded separately. a: Grade 3 staining for HB-EGF in the urothelium and lamina propria (magnification 200×). b: Grade 1 staining for HB-EGF in the urothelium and lamina propria (magnification 200×). c: Urothelial HB-EGF staining intensity was significantly associated with urine IL-8 levels in untreated IC/PBS patients. Urine IL-8 was analyzed by ELISA and normalized to urine creatinine. Bars represent median values for IL-8 in each staining category.

Bladder biopsies were stained with anti-HB-EGF primary antibody followed by a standard streptavidin method. HB-EGF staining was graded semiquantitatively from 0 (none) to 3 (intense). On each biopsy the urothelium and lamina propria were graded separately. a: Grade 3 staining for HB-EGF in the urothelium and lamina propria (magnification 200×). b: Grade 1 staining for HB-EGF in the urothelium and lamina propria (magnification 200×). c: Urothelial HB-EGF staining intensity was significantly associated with urine IL-8 levels in untreated IC/PBS patients. Urine IL-8 was analyzed by ELISA and normalized to urine creatinine. Bars represent median values for IL-8 in each staining category.