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. Author manuscript; available in PMC: 2009 Jul 4.
Published in final edited form as: J Urol. 2008 Mar 18;179(5):1850–1856. doi: 10.1016/j.juro.2008.01.047

Figure 4.

Figure 4

Figure 4

Figure 4

Mast cells were detected by staining bladder biopsies with anti-tryptase primary antibody followed by a standard streptavidin method. An optical reticle was used to count mast cells in the urothelium, lamina propria and detrusor. a: Brisk mastocytosis in the lamina propria (magnification 200×). b: Minimal mastocytosis in the lamina propria (magnification 200×). c: Scatter plot of urine IL-8 levels vs. mast cell count in the lamina propria for untreated IC/PBS patients. Lamina propria mast cell count was significantly associated with urine IL-8, which was analyzed by ELISA and normalized to urine creatinine.