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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Future Oncol. 2009 Mar;5(2):187–196. doi: 10.2217/14796694.5.2.187

Figure 1. Two-signal model of T-cell dependence on costimulation.

Figure 1

The second (costimulatory) signal is required for T-cell cytokine production and proliferation.

MHC: Major histocompatibility complex; TCR: T-cell receptor.

Reprinted with permission from [66].