Table 2.
Selected genes exhibiting > fourfold commonly downregulated expression in H526 cells treated with oxoplatin or cisplatin compared to untreated control cells classified according to their cellular function. For gene expression analysis H526 SCLC cells were treated with 3.75 μM oxoplatin or 4.1 μM cisplatin, respectively, in tissue culture flasks for three days. Thereafter, RNA of control and treated cells was extracted, and gene expression was analyzed using Applied Biosystems Human Genome Survey Microarray V2.0.
| Cellular process | Locus link | Gene symbol | Gene name |
|---|---|---|---|
| Transcription | 4150 | MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) |
| 3221 | HOXC4 | Homeo box C4 | |
| 10658 | CUGBP1 | CUG triplet repeat, RNA binding protein 1 | |
|
| |||
| Apoptosis | 8771 | TNFRSF6B | Tumor necrosis factor receptor superfamily, member 6b, decoy |
| 598 | BCL2L1 | BCL2-like 1 | |
| 3855 | KRT7 | Keratin 7 | |
|
| |||
| Cytoskeleton | 347733 | MGC8685 | Tubulin, beta polypeptide paralog |
| 823 | CAPN1 | Calpain 1, (mu/I) large subunit | |
| 50861 | STMN3 | Stathmin-like 3 | |
| 5962 | RDX | Radixin | |
| 977 | CD151 | CD151 antigen | |
| 50512 | PODLX2 | Endoglycan | |
| 55920 | TD-60 | RCC1-like | |
| 91179 | SCARF2 | Scavenger receptor class F, member 2 | |
| 6711 | SPTBN1 | Spectrin, beta, nonerythrocytic 1 | |
| 6596 | SMARCA3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 | |
| 4134 | MAP4 | Microtubule-associated protein 4 | |
|
| |||
| Signal transduction | 51582 | OAZIN | Ornithine decarboxylase antizyme inhibitor |
| 26469 | PTPN18 | Protein tyrosine phosphatase, nonreceptor type 18 (brain-derived) | |
| 11247 | NXPH4 | Neurexophilin 4 | |
| 53944 | CSNK1G1 | Casein kinase 1, gamma 1 | |
| 1445 | CSK | C-src tyrosine kinase | |
| 30851 | TIP-1 | Tax interaction protein 1 | |
| 23187 | PHLDB1 | Pleckstrin homology-like domain, family B, member 1 | |
| 3597 | IL13RA1 | Interleukin 13 receptor, alpha 1 | |
|
| |||
| Metabolism | 2539 | G6PD | Glucose-6-phosphate dehydrogenase |
| 5211 | PFKL | Phosphofructokinase, liver | |
| 2542 | SLC37A4 | Solute carrier family 37 (glycerol-6-phosphate transporter), member 4 | |
| 478 | ATP1A3 | ATPase, Na+/K+ transporting, alpha 3 polypeptide | |
| 55611 | OTUB1 | OTU domain, ubiquitin aldehyde binding 1 | |
| 2030 | SLC29A1 | Solute carrier family 29 (nucleoside transporters), member 1 | |
| 6566 | SLC16A1 | solute carrier family 16 (monocarboxylic acid transporters), member 1 | |
|
| |||
| Transport | 29924 | EPN1 | Epsin 1 |
| 6844 | VAMP2 | Vesicle-associated membrane protein 2 (synaptobrevin 2) | |
| 10527 | IPO7 | Importin 7 | |
| 7514 | XPO1 | Exportin 1 (CRM1 homolog, yeast) | |
| 1654 | DDX3X | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | |