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Systemic administration of r-Hu-EPO ameliorates EAE. Lewis rats receiving r-Hu-EPO (5,000 units/kg BW) beginning at day 3 after immunization with myelin basic protein demonstrate both a delay in onset and a marked reduction of clinical symptoms (n = 18 animals in each group, three separate experiments; **, P < 0.01; *, P < 0.05).
