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Systemic administration of r-Hu-EPO delays and lessens kainate-induced seizures. (A) Mortality subsequent to a convulsant dosage of kainate (20 mg/kg BW i.p.) is significantly reduced (P < 0.01) by a 24-h pretreatment of mice with r-Hu-EPO (5,000 units/kg BW i.p.). (B) A single dose of r-Hu-EPO (5,000 units/kg BW) administered on day 0, 1, 2, 3, or 7 before testing continues to provide protection from kainate (n = 18, 36, 17, 8, or 8 respectively; *, P < 0.05 compared with control).
