Table 2.

Rate Parameters Descriptive of FXII Autoactivation in Human Plasma

			Hydrophilic/Hydrophobic
Procoagulant	βka ×10−5 (%R2, N=5)	kiPF12 ×10−3 (%R2, N=5)	${(k_a)}^{\mathit{philic}}/{(k_a)}^{\mathit{phobic}}$	${(k_i{P}_{F12})}^{\mathit{philic}}/{(k_i{P}_{F12})}^{\mathit{phobic}}$
Hydrophilic	15.2±2.9 (90.3)	6.3±1.5 (84.5)	2.69	0.40
Hydrophobic	5.64±0.67 (95.9)	15.6±1.9 (95.6)

Notes: Procoagulants = 150 mm² nominal surface area of water-wettable (hydrophilic) and silanized-glass (hydrophobic) particles (see Methods and Materials). Listed error are standard errors of the fit to Eqs. 7, 8 of Appendix I.