Table 4.

Estimated Absolute and Ratio Rate Parameters Descriptive of FXII Autoactivation

	Hydrophilic			Hydrophobic			Hydrophilic/Hydrophobic Ratio
Parameter	Buffer	Cocktail	Plasma	Buffer	Cocktail	Plasma	Buffer	Cocktail	Plasma
ka (sec−1)			15.2×10−3			5.6×10−3			2.7
ki (mL/mgsec)			6.3×10−3			15.6×10−5			40.4
$k_i/k_a$ (mL/mg)	5.1×10−1	3.3×10−1	4.1×10−1	3.8 ×10−3	7.4×10−3	2.7×10−2	134	44.6	15.2
Buffer:cocktail Ratio	1.6			0.5			3.2

Notes: Data of Tables 2 and 3 recalculated using the estimate β = 0.01 and further assuming P_F12 = 100 for hydrophobic procoagulants P_F12 = 1 for hydrophilic procoagulants.