Table 1A.

Identification of MicroRNA Associated with the Central Nervous System

MicroRNA	Cell/Tissue	Target1.	Functions	Sp.	Ref.2.
Down-Regulated
miR-9, 131	Presenilin 1 knockout	-	Brain development	m	[72]
miR-130a, 206	Mesenchymal stem cell	TAC1	Neurotransmission	h	[73]
Up-Regulated
let-7a/c/e	P19; embryo	-	Neuronal speciation	m	[50]
miR-7	Vasotocinergic neuron	-	Neurosecretion	z	[74]
miR-9-1	Embryo	Fgf genes	CNS development	z	[75]
miR-9a	Sensory organs	Senseless	Sensory neuron	d	[76]
let-7g, miR-21, 27a/b, 29a, 138	SH-SY5Y	-	Neurogenesis		[77]
miR-23	NT2	HES1	Neurogenesis	h	[78]
miR-26a	Hippocampus	MAP2	Dendrite	r	[79]
miR-30a-5p	Prefrontal Cortex	BDNF	Cortical development & function	h	[80]
miR-124	P19; neural tube	SCP1	CNS development	c/m	[81]
miR-124	Neural tube	LAMC1 ITGB1	Neuronal speciation	c	[82]
miR-124	CAD; N2a	PTBP1	Brain-specific alternative splicing; Neurogenesis	m	[83]
miR-125b	P19	Lin-28	Neurogenesis	m	[84]
miR-132	PC12; neuron	p250GAP	Neuronal plasticity	r	[85]
miR-134	Hippocampus	Limk1	Dendrite & synapse	m/r	[86]
miR-184	Cortical neurons	-	Synaptic plasticity (DNA methylation)	m	[87]
miR-200 family	Embryo	neuroD, foxg1, lfng, zfhx1	Olfactory neurogenesis	m/z	[88]
miR-200b	Hippocampus	ZFHX1B	CNS development; TGFβ-signaling	m	[89]
miR-204	Choroid plexus	TRPM3	CSF associated	m	[90]
miR-430	Embryo	-	Brain morphogenesis	z	[91]

^1.Reported miRNA target’s gene symbol: APP, amyloid precursor protein; BACE1, β-site APP cleaving enzyme 1; BDNF, Brain-derived neurotrophic factor; CFH, Complement factor H; fgf, fibroblast growth factor; GRIA2, Glutamate receptor subunit; HES1, Hairy and enhancer of split 1; ITGB1, Integrin β1; LAMC1, laminin γ1; Limk1, Lim-domain-containing protein kinase; MAP2, Microtubule -associated protein 2; p250GAP, p250GTPase-activating protein; PITX3, Paired-like homeodomain transcription factor Pitx3; PTBP1, Polypyrimidine tract binding protein 1, PTB/hnRNPI; SCP1, Small C-terminal domain phosphatase 1; SLITRK1, Slit and Trk-like 1; TAC1, Tachykinin; TRPM3, Transient receptor potential cation channel M3; VSNL1, Visinin-like 1; ZFHX1B, Zinc finger E-box binding homeobox 2, ZEB2.

^2.The common or significantly altered miRNAs are reported from published microarray profiling data.