Table 2.

Similarly Altered Patterns of MicroRNA Expression in Alzheimer Disease and Aging Model Systems

MicroRNA1	Alzheimer Disease Affected Tissue					Aging Model	Reference
	Cortex	Hippocampus	Cerebellum	CSF	PBMC
Down-Regulated
let-7i	↓					↓	[96,169]
miR-9	↓	↓	↓				[99, 96]
miR-15	↓			↓			[99, 96]
miR-146b	↓	↓	↓	↓			[99]
miR-181c	↓			↓			[99, 96]
miR-210	↓	↓					[99, 96]
miR-338	↓			↓			[99, 96]
miR-451				↓		↓	[99, 169]
Up-Regulated
let-7f				↑	↑	↑	[99, 39, 181]
miR-30d				↑		↑	[99, 169]
miR-34a	↑	↑	↑		↑	↑	[39, 99, 169, 170]
miR-125b	↑	↑	↑				[99, 98]
miR-197	↑			↑			[99, 96]
miR-200a	↑				↑		[99, 39]
miR-371				↑	↑		[99, 39]
miR-517				↑	↑	↑	[99, 39]
miR-520h	↑				↑		[96, 39]

^1.MicroRNAs that show similar expression trends in the various AD tissues and aging models are reported. Distinct sets of miRNAs expressed in the different systems are not shown.