Fig. (1).

Domain organization of TOR kinases. Functional domains depicted include the N-terminal HEAT repeats, the central FAT domain, the kinase domain, and the C-terminal FRB domain to which FKBP12-rapamycin associates. Proteins associating with TORC1 include TCO89, KOG1, and LST1, of which only TCO89 has no apparent mammalian homolog.