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. 2009 Jun 26;41(6):406–416. doi: 10.3858/emm.2009.41.6.046

Figure 4.

Figure 4

SRE-1 is not required for PGC-1α-mediated inhibition of LDLR promoter activity. HepG2 cells were transfected with LacZ expression vector, expression vectors (400 ng) for PGC-1α or mock vector (pcDNA3.1/HisC), and one of three LDLR promoter reporter genes (800 ng), wild type pLR1563-luc (WT), pLR1563 without SRE-1 (dSRE-luc), pLR1563 with scrambled SRE-1 (mSRE-luc), as indicated. Normalized luciferase expressions from triplicate samples were calculated relative to the LacZ expressions, and the results were expressed as % control over the value obtained with the reporter alone. Values are mean ± SD of three independent duplicate experiments. *: P < 0.05 vs. mock control.