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. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Basic Res Cardiol. 2008 Jul 3;103(5):407–416. doi: 10.1007/s00395-008-0725-0

Fig. 1.

Fig. 1

Fold change of TNFα mRNA expression (real-time PCR) is significantly higher in db/db than in Db/db controls aged 6 (A), 12 (B), 18 (C) and 24 (D) weeks and TNFα mRNA expression is also higher in Db/db controls at 18 and 24 weeks Vs. 6 and 12 weeks of Db/db mice. The mRNA expression is the highest in db/db mice aged 24 weeks. In Db/db controls, TNFα significantly increases with age at 18 and 24 weeks. Normalization of TNFα transcripts with β-actin transcripts demonstrated a significantly greater expression of TNFα in the coronary arterioles of db/db Vs. Db/db mice. Data represent mean ± SD, n = 6. * P < 0.05 Vs. Db/db mice (6 and 12 weeks); # P < 0.05 Vs. Db/db mice (18 and 24 weeks)