Fig. 4.

At 12 weeks, anti-TNFα restored NO-mediated coronary arteriolar dilation in db/db mice, but did not affect the vasodilation to ACh in Db/db mice (a, n = 6). a Shows that FID was abrogated in db/db mice (n = 5), but similar to the response for ACh; anti-TNFα restored FID to near control levels (n = 4). Anti-TNFα did not affect dilation of control vessels. At 24 weeks, anti-TNF restored NO-mediated coronary arteriolar dilation in db/db and Db/db mice (b). b Shows that FID in mice of 24 weeks was abrogated in db/db and Db/db mice, and anti-TNFα restored FID at Db/db mice at 24 weeks to the control levels of Db/db mice aged 12 weeks (n = 6), but just partially restored FID at db/db mice aged 24 weeks (n = 4). * P < 0.05 Vs. db/db and # P < 0.05 Vs. Db/db mice