Table 2.
Hazard ratios (HRs) of Total Mortality According to Quartiles of BMI at Various Ages and Average Adult BMI
| All Subjects Aged 51–70 y at Baseline (n=26055) |
Excluding Subjects Potentially Contributing to Bias* (n=19883) |
||||
|---|---|---|---|---|---|
| Quartile of BMI, kg/m2 | No. of Deaths | Age-Adjusted HR (95% CI) |
No. of Deaths | Age-Adjusted HR (95% CI) |
Multivariate HR† (95% CI) |
| BMI at study baseline | |||||
| <22.2 | 291 | 1 (Reference) | 87 | 1 (Reference) | 1 (Reference) |
| 22.2–24.3 | 244 | 0.84 (0.71–0.99) | 105 | 1.15 (0.86–1.52) | 1.13 (0.85–1.50) |
| 24.4–26.6 | 299 | 1.01 (0.86–1.18) | 133 | 1.47 (1.12–1.92) | 1.40 (1.07–1.84) |
| ≥26.7 | 353 | 1.11 (0.95–1.30) | 161 | 1.74 (1.34–2.25) | 1.61 (1.23–2.10) |
| P value for trend | 0.04 | <.0001 | 0.0001 | ||
| BMI at age 50 y | |||||
| <21.1 | 245 | 1 (Reference) | 91 | 1 (Reference) | 1 (Reference) |
| 21.1–23.0 | 238 | 0.99 (0.82–1.18) | 116 | 1.34 (1.02–1.76) | 1.32 (1.00–1.74) |
| 23.1–25.3 | 292 | 1.29 (1.08–1.52) | 132 | 1.74 (1.33–2.28) | 1.67 (1.28–2.19) |
| ≥25.4 | 412 | 1.73 (1.47–2.02) | 147 | 2.06 (1.58–2.67) | 1.91 (1.46–2.50) |
| P value for trend | <.0001 | <.0001 | <.0001 | ||
| BMI at age 20 y | |||||
| <18.0 | 297 | 1 (Reference) | 116 | 1 (Reference) | 1 (Reference) |
| 18.0–19.4 | 276 | 0.92 (0.78–1.09) | 117 | 1.03 (0.80–1.34) | 1.02 (0.79–1.32) |
| 19.5–21.3 | 247 | 0.91 (0.77–1.08) | 106 | 1.03 (0.79–1.33) | 1.01 (0.77–1.31) |
| ≥21.4 | 367 | 1.19 (1.02–1.39) | 147 | 1.34 (1.05–1.71) | 1.29 (1.01–1.64) |
| P value for trend | 0.01 | 0.02 | 0.04 | ||
| Average Adult BMI | |||||
| <20.9 | 250 | 1 (Reference) | 78 | 1 (Reference) | 1 (Reference) |
| 20.9–22.4 | 267 | 1.06 (0.89–1.26) | 127 | 1.66 (1.25–2.21) | 1.63 (1.23–2.17) |
| 22.5–24.0 | 292 | 1.14 (0.96–1.35) | 124 | 1.70 (1.28–2.25) | 1.61 (1.21–2.15) |
| ≥24.1 | 378 | 1.44 (1.23–1.69) | 157 | 2.19 (1.67–2.88) | 2.02 (1.53–2.66) |
| P value for trend | <.0001 | <.0001 | <.0001 | ||
Abbreviations: BMI, body mass index; CI, confidence interval.
*
Excluding subjects who ever smoked, reported previous cardiovascular disease or cancer at baseline or substantial weight loss since age 50, or died within the first 3 years of follow-up.
†
Analyses of BMI at baseline, age 50, and average BMI adjusted for age; education; occupation; annual family income; menopausal status; hormone therapy; amount of exercise; alcohol consumption; intakes of saturated fat, vegetables, and fruits. For BMI at age 20, adjusted for age and amount of exercise during adolescence.