Table 3.
Hazard ratios (HRs) of Cardiovascular or Cancer Mortality by Quartiles of BMI After Excluding Subjects Potentially Contributing to Bias* (n=19883)
| Cardiovascular Mortality | Cancer Mortality | |||||
|---|---|---|---|---|---|---|
| Quartile of BMI, kg/m2 | No. of Deaths | Age-Adjusted HR (95% CI) |
Multivariate HR (95% CI) |
No. of Deaths | Age-Adjusted HR (95% CI) |
Multivariate HR† (95% CI) |
| BMI at study baseline | ||||||
| <22.2 | 13 | 1 (Reference) | 1 (Reference) | 48 | 1 (Reference) | 1 (Reference) |
| 22.2–24.3 | 16 | 1.17 (0.56–2.43) | 1.13 (0.54–2.35) | 61 | 1.21 (0.83–1.77) | 1.19 (0.82–1.74) |
| 24.4–26.6 | 31 | 2.30 (1.20–4.39) | 2.14 (1.11–4.10) | 77 | 1.54 (1.07–2.21) | 1.49 (1.03–2.14) |
| ≥26.7 | 36 | 2.59 (1.37–4.89) | 2.27 (1.19–4.33) | 89 | 1.76 (1.24–2.50) | 1.68 (1.18–2.41) |
| P value for trend | 0.0004 | 0.003 | 0.0006 | 0.002 | ||
| BMI at age 50 y | ||||||
| <21.1 | 17 | 1 (Reference) | 1 (Reference) | 50 | 1 (Reference) | 1 (Reference) |
| 21.1–23.0 | 17 | 1.04 (0.53–2.04) | 1.03 (0.52–2.01) | 72 | 1.52 (1.06–2.19) | 1.52 (1.06–2.18) |
| 23.1–25.3 | 29 | 2.03 (1.12–3.70) | 1.90 (1.04–3.47) | 72 | 1.74 (1.21–2.50) | 1.70 (1.18–2.45) |
| ≥25.4 | 33 | 2.45 (1.37–4.41) | 2.15 (1.18–3.89) | 81 | 2.09 (1.46–2.97) | 2.00 (1.39–2.86) |
| P value for trend | 0.0003 | 0.003 | <.0001 | 0.0002 | ||
| BMI at age 20 y | ||||||
| <18.0 | 23 | 1 (Reference) | 1 (Reference) | 61 | 1 (Reference) | 1 (Reference) |
| 18.0–19.4 | 17 | 0.75 (0.40–1.40) | 0.75 (0.40–1.40) | 78 | 1.33 (0.95–1.86) | 1.31 (0.94–1.84) |
| 19.5–21.3 | 23 | 1.11 (0.62–1.98) | 1.10 (0.62–1.96) | 59 | 1.10 (0.77–1.57) | 1.08 (0.75–1.54) |
| ≥21.4 | 33 | 1.48 (0.87–2.53) | 1.45 (0.85–2.48) | 77 | 1.35 (0.96–1.90) | 1.32 (0.94–1.85) |
| P value for trend | 0.06 | 0.07 | 0.2 | 0.2 | ||
| Average Adult BMI | ||||||
| <20.9 | 12 | 1 (Reference) | 1 (Reference) | 43 | 1 (Reference) | 1 (Reference) |
| 20.9–22.4 | 25 | 2.14 (1.08–4.27) | 2.03 (1.02–4.05) | 76 | 1.80 (1.24–2.62) | 1.78 (1.22–2.60) |
| 22.5–24.0 | 23 | 2.04 (1.01–4.10) | 1.86 (0.92–3.75) | 71 | 1.77 (1.21–2.59) | 1.72 (1.17–2.52) |
| ≥24.1 | 36 | 3.26 (1.69–6.26) | 2.75 (1.42–5.36) | 85 | 2.17 (1.51–3.14) | 2.07 (1.42–3.01) |
| P value for trend | 0.0005 | 0.004 | 0.0001 | 0.0005 | ||
Abbreviations: BMI, body mass index; CI, confidence interval.
*
Excluding subjects who ever smoked, reported previous cardiovascular disease or cancer at baseline or substantial weight loss since age 50, or died within the first 3 years of follow-up.
†
Analyses of BMI at baseline, age 50, and average BMI adjusted for age; education; occupation; annual family income; menopausal status; hormone therapy; amount of exercise during the past 5 years; alcohol consumption; intakes of saturated fat, vegetables, and fruits. For BMI at age 20, adjusted for age and amount of exercise during adolescence.