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. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2009 Apr 20;19(11):3023–3026. doi: 10.1016/j.bmcl.2009.04.058

Table 2.

In vitro HDAC inhibitory assay results for compounds 6–15.

	IC₅₀ (nM)
Compds	HDAC1	HDAC2	HDAC3	HDAC6	HDAC10
6	303 ± 22	430 ± 37	30 ± 1	68 ± 5	254 ± 25
7	139 ± 4	164 ± 4	25 ± 1	82 ± 5	250 ± 6
8	>30,000	>30,000	>30,000	>30,000	>30,000
9	>30,000	>30,000	10,600 ± 829	>30,000	>30,000
10	>30,000	>30,000	>30,000	>30,000	>30,000
11	328 ± 10	469 ± 18	102 ± 3	51 ± 0.9	471 ± 20
12	885	3,750	7,410	885	ND^a
13	17,100	> 30,000	nd^a	17,100	ND^a
14	12,300	> 30,000	> 30,000	12,300	ND^a
15	9,200 ± 670	>30,000	1,920 ± 73	1710 ± 82	13,300 ± 560
SAHA^b	96	282	17	14	72

^a

ND = Not Detected.

^b

SAHA data provided by Amphora Inc.