Skip to main content
. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Mutat Res. 2007 Nov 29;650(2):181–195. doi: 10.1016/j.mrgentox.2007.11.006

Figure 2.

Figure 2

Mitomycin C data: cytotoxicity (panels A and B) and genotoxicity (panels C and D). Panels A and B: Lines correspond to each of several cytotoxicity endpoints whose data are expressed as percent viability relative to solvent control. These data should be read on the Y-axis. White bars correspond to EMA-fold increase data, and these cytotoxicity measurements should be read on the YY-axis. For convenience, a dashed line has been added to denote the 40% relative survival value that has been cited as an appropriate means for choosing top concentration. Panels C and D: Fold increase in mean micronuclei frequencies as measured by flow cytometry (white bars) and by microscopy (black bars) are shown. Asterisks (*) signify ≥ 3-fold micronucleus induction. Brackets indicate concentrations that were deemed overly cytotoxic by the Flow-NBR technique.