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. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Clin Cancer Res. 2008 Aug 1;14(15):4971–4980. doi: 10.1158/1078-0432.CCR-08-0473

Figure 3. GRN163L inhibits telomerase activity in adenocarcinoma cells.

Figure 3

A. Structure of GRN163L, a Palmitoyl (C16) lipid – attached oligonucleotide targeting RNA component of telomerase. B. Uptake of GRN163L in SEG-1 cells without any need of transfection. Cells were treated with TAMRA-labeled GRN163L for 24 hrs and examined by a multiphoton fluorescence microscope. Uptake can be seen as red fluorescence. C – D. Telomerase activity in cells treated with a mismatch control oligonucleotide (MM) or GRN163L. SEG-1 (C) and FLO-1 (D) were treated with GRN163L at various concentrations for 24 hrs and evaluated for telomerase activity using TRAPeze XL Telomerase Detection Kit.