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The apoptotic pathway in Drosophila. In response to apoptotic stimuli, expression of the pro-apoptotic genes hid, reaper and grim releases the initiator caspase Dronc from inhibition by Diap1. Free Dronc then associates with the adaptor protein Ark and proteolytically processes the effector caspases DrICE and Dcp-1 to induce apoptosis.
