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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Mol Pharm. 2009;6(3):971–977. doi: 10.1021/mp900006h

Figure 4.

Figure 4

In vivo anti-tumor efficacy of CL loaded with D-(KLAKLAK)2/G3139 in the tumor-bearing mice. The mice bearing B16(F10) tumors were administered via intratumoral injection with CL loaded with D-(KLAKLAK)2/G3139 or G3139 alone, CL(peptide/G3139) and CL(G3139) respectively. After 4 days post-injection, (a) tumor volumes were measured and (b) relative inhibition of tumor growth was accessed by comparing tumor volumes of the treated animals to saline-treated controls. Intra-tumoral administration of CL(peptide/G3139) led to significantly decreased tumor volumes whereas CL(G3139) alone showed no significant decrease (n=4, one-way ANOVA followed by Tukey post-hoc test).