Antibody response (mean + SD) determined by IFA at 5 wk postexposure sorted by MHC haplotype. Mice of the q haplotype (FVB/N, NMRI, ICR) showed lower antibody levels than did mice of the b (C57BL/6J) and d (BALB/c, DBA2J) haplotype. Furthermore, mice of the b haplotype responded with increased levels of specific antibodies compared with those of the intermediate-responding mice of the d and k (AKR/N, C3H/HeN) haplotypes. Differences were determined by the Kruskal–Wallis test (P = 0.0009) and subsequent Mann–Whitney U tests.