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. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Best Pract Res Clin Gastroenterol. 2008;22(3):411–423. doi: 10.1016/j.bpg.2007.10.023

Figure 1.

Figure 1

Schematic representation of eosinophil maturation and trafficking. Eosinophils differentiate from hematopoietic progenitor cells into mature eosinophils in the bone marrow under the control of critical transcription factors, especially GATA-1. The eosinophil-promoting cytokines, IL-3, GM-CSF, and IL-5, regulate eosinophil expansion. Eosinophil migration from the bone marrow into the peripheral circulation is primarily regulated by IL-5. Circulating eosinophils interact with the endothelium in the gastrointestinal tract by a regulated process involving the coordinated interaction between adhesion molecules, chemokines and their receptors.