Table 13.3.
Paraneoplastic and non-paraneoplastic antibodies often associated with limbic encephalopathy
Antibodies | Tumors | Usual Age of Onset | Gender | Associated Symptoms |
---|---|---|---|---|
Anti-Hu | SCLC, neuroblastoma, prostate | 55-65 | F>=M | PEM; SSN |
Anti- Ma2 (anti-Ta) | Germinoma, testicular; lung Ca | 22-45 | M≫F | PLE; Brainstem; Cerebellar; Hypothalamic |
Anti-CV2 (Anti-CRMP-5) | Thymoma, lung Ca, renal cell | 50-70 | F=M | Neuropathy, Cerebellar, PLE, Chorea |
Anti- VGKC | 80% none; 20% tumor thymoma, lung, | variable | ??? | Isaac's and Morvan's Syndromes; neuromyotonia, cramps, hyperhydrosis, sleep disorder, seizures PLE |
Anti-amphiphysin | Breast, SCLC | PEM, Stiff Person's Syndrome, Opsoclonus-myoclonus | ||
Anti-Yo | Gynecologic and breast, adenoCa | 26-85 | F≫M | PCD; Limbic encephalopathy |
Anti-nCMAg (some anti-neuropil) | Teratomas, thymus | 20-50s | F>M | Acute PLE, abnormal movements, decreased consciousness |
Anti-Ma1 | Lung, other (breast, parotid, colon) | 60 | F | PCD; brainstem |
Anti-Ri (ANNA-2) | Breast, gynecologic, lung, bladder | Ataxia; opsoclonus/myoclonus |