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. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Neurol Clin. 2007 Aug;25(3):783–vii. doi: 10.1016/j.ncl.2007.04.001

Table 13.3.

Paraneoplastic and non-paraneoplastic antibodies often associated with limbic encephalopathy

Antibodies Tumors Usual Age of Onset Gender Associated Symptoms
Anti-Hu SCLC, neuroblastoma, prostate 55-65 F>=M PEM; SSN
Anti- Ma2 (anti-Ta) Germinoma, testicular; lung Ca 22-45 M≫F PLE; Brainstem; Cerebellar; Hypothalamic
Anti-CV2 (Anti-CRMP-5) Thymoma, lung Ca, renal cell 50-70 F=M Neuropathy, Cerebellar, PLE, Chorea
Anti- VGKC 80% none; 20% tumor thymoma, lung, variable ??? Isaac's and Morvan's Syndromes; neuromyotonia, cramps, hyperhydrosis, sleep disorder, seizures PLE
Anti-amphiphysin Breast, SCLC PEM, Stiff Person's Syndrome, Opsoclonus-myoclonus
Anti-Yo Gynecologic and breast, adenoCa 26-85 F≫M PCD; Limbic encephalopathy
Anti-nCMAg (some anti-neuropil) Teratomas, thymus 20-50s F>M Acute PLE, abnormal movements, decreased consciousness
Anti-Ma1 Lung, other (breast, parotid, colon) 60 F PCD; brainstem
Anti-Ri (ANNA-2) Breast, gynecologic, lung, bladder Ataxia; opsoclonus/myoclonus

SCLS = small cell lung cancer; PLE = paraneoplastic limbic encephalopathy; PEM = paraneoplastic encephalomyelitis; SSN=subacute sensory neuropathy; PCD= Paraneoplastic cerebellar degeneration; nCMAg = novel cell membrane antigen References: [52-54, 151-160]

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