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. Author manuscript; available in PMC: 2009 Jul 6.
Published in final edited form as: Neuromolecular Med. 2009 May 6;11(2):58–62. doi: 10.1007/s12017-009-8064-3

Figure 2.

Figure 2

A decline of daily running distance, and to a lesser extent running speed, occurs prior to the onset of clinical symptoms in ALS mice. Examples of the time course of changes in daily running distance and average running speed (each expressed as a percentage of the maximum), in relation to the onset of clinical symptoms (ALS score) in four different mSOD1 mice. Note that a decline in daily running distance presaged the onset of symptoms by 10–20 days, and that a decrease in average running speed occurred prior to the onset of symptoms but after the decline in running distance. These four examples are representative of the results in all 15 mice examined.