Table 1.
Baseline characteristics (age 60–79) of the MI case and control populations: mean (SD) unless otherwise specified.a.
| MI cases (n = 362) | MI controls (n = 698) | Difference (p-value) | |
|---|---|---|---|
| Demographic/questionnaire | |||
| Age (years) | 70.91 (5.48) | 70.80 (5.44) | Matched |
| Male, n (%) | 267 (73.6) | 512 (73.1) | Matched |
| Northern region of residence, n (%)b | 150 (41.0) | 286 (41.4) | Matched |
| Non-manual occupation, n (%)b | 152 (44.4) | 319 (47.9) | 0.298 |
| Prior evidence of MI or stroke, n (%) | 107 (29.6) | 117 (16.8) | <0.001 |
| History of diabetes, n (%) | 55 (20.6) | 55 (10.7) | <0.001 |
| 1–2 alcoholic drinks/day, n (%) | 126 (37.8) | 299 (46.4) | 0.010 |
| Current smoker, n (%) | 75 (20.72) | 93 (13.3) | 0.004 |
| Physical activity (inactive/occasional), n (%) | 231 (66.4) | 391 (58.6) | 0.016 |
| Physical measurements | |||
| Body mass index (kg/m2)c,d | 27.11 (4.26) | 27.02 (3.95) | 0.728 |
| Systolic blood pressure (mmHg)c,d,e | 153.94 (27.22) | 148.55 (24.16) | 0.001 |
| Diastolic blood pressure (mmHg)c,d,e | 83.85 (12.07) | 83.22 (11.52) | 0.409 |
| FEV1 (L/min)c,d,f | 2.15 (0.55) | 2.23 (0.60) | 0.028 |
| Lipids/metabolic markers | |||
| Total cholesterol (mMol/L)c | 6.24 (1.22) | 6.08 (1.07) | 0.027 |
| HDL cholesterol (mMol/L)c | 1.31 (0.33) | 1.41 (0.36) | <0.001 |
| Triglyceride (mMol/L)c,e,g | 1.80 (1.32, 2.40) | 1.58 (1.14, 2.12) | <0.001 |
| Insulin (mU/L)c,e,g | 9.25 (5.57, 13.61) | 7.85 (5.37, 11.07) | <0.001 |
| Glucose (mMol/L)c,e,g | 6.19 (5.36, 6.38) | 5.84 (5.37, 6.12) | <0.001 |
| Inflammatory and haemostatic markers | |||
| TNFα(pg/mL)c,g | 1.84 (1.29, 2.42) | 1.63 (1.19, 2.18) | <0.001 |
| C-Reactive Protein (mg/L)c,g | 2.41(1.08, 5.58) | 1.77 (0.90, 3.60) | <0.001 |
| IL-6(pg/mL)c,e,g | 2.99 (1.89, 4.26) | 2.43 (1.54, 3.47) | <0.001 |
| Fibrinogen (g/L)c,e,g | 3.47 (3.03, 3.98) | 3.26 (2.85, 3.75) | <0.001 |
| White cell count (^109/L)c,e,g | 7.27 (6.01, 8.84) | 6.80 (5.68, 7.98) | <0.001 |
a
Case–control sample is maximum available.
b
Reported in 1978–1980 (age 40–59 years) for men and in 1998–2000 (age 60–79 years) for women.
c
Adjusted for gender, age at survey and region of residence (Scotland, North, Midlands and South).
d
Adjusted for nurse number.
e
Adjusted for time of day.
f
Adjusted for height squared.
g
Analysed as natural log transformed variable, geometric mean (IQR) reported on original scale.