Table 4.
Odds ratio (95% CI) of MI in men and women with TNFα values in the higher tertiles compared to the lower tertile of the distribution (n = 867).a.
| TNFα | MI cases | MI controls | OR (95% CI) with adjustments |
|||
|---|---|---|---|---|---|---|
| Tertiles | Model 1 | Model 2 | Model 3 | Model 4 | ||
| Range (pg/mL) | ||||||
| 1.89–22.90 | 128 | 186 | 1.75 (1.22, 2.49) | 1.47 (1.01, 2.14) | 1.44 (0.99, 2.11) | 1.33 (0.91, 1.96) |
| 1.31–1.88 | 84 | 203 | 1.03 (0.71, 1.48) | 0.99 (0.67, 1.44) | 0.98 (0.67, 1.44) | 0.94 (0.64, 1.39) |
| 0.03–1.30 | 77 | 189 | 1 | 1 | 1 | 1 |
| Total | 289 | 578 | p = 0.002 | p = 0.038 | p = 0.049 | p = 0.125 |
| Continuous | Model 1 | Model 2 | Model 3 | Model 4 | ||
| 1 log2 (TNFα)b | 289 | 578 | 1.34 (1.11, 1.60) | 1.25 (1.03, 1.51) | 1.23 (1.02, 1.49) | 1.18 (0.97, 1.43) |
Model 1 = age, gender and region.
Model 2 = model 1 + smoking, alcohol, physical activity, history of diabetes, BMI, SBP, DBP, TC, HDL.
Model 3 = model 2 + insulin + glucose.
Model 4 = model 3 + IL-6 + CRP.
a
Complete case analysis sample. Tertiles based on control group. p-value for test for trend over tertiles.
b
OR of MI per 1 log2 increase in log 2(TNFα), i.e. doubling of TNFα.