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Canonical fold of α/β-hydrolases. a Topology diagram, with the strands indicated by red arrows and the helices by cyan cylinders. The positions of the catalytic residues are indicated. b–d The structures of three hyperthermophilic esterases: b the carboxylesterase AFEST from A. fulgidus (pdb 1JJI), c the esterase EstA from T. maritima (pdb 3DOH), and d the acylpeptide hydrolase apAPH from A. pernix (pdb 1VE6)
