Fig. 2.

Outcome of acute mechanical cartilage injury. (A) H&E (left) and safranin-O (right) staining of sections from sham operated and injured joints of 8 weeks old C57BL/6 and DBA/1 mice at the indicated time points. (B) Higher magnification of H&E stained sections from injured C57BL/6 showing areas away from the experimental lesion with various degrees of OA. (C–D), repair score (C) and modified Mankin score (D) at 4 (n = 5) and 8 (n = 15) weeks time points. Low score in C indicated better repair and high score in D indicated more severe OA. All the values are expressed as mean ± standard error of the mean (s.e.m.). *P < 0.05. [For interpretation of color in this figure legend, the reader is referred to web version of the article.]