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Aggrecan degradation. Immunostaining of aggrecanase (TEGE373, A) and MMPs (VDIPEN, B) generated neoepitope (brown) in the articular cartilage of 8-week-old C57BL/6 and DBA/1. Nuclei are counterstained with hematoxylin (blue). [For interpretation of color in this figure legend, the reader is referred to web version of the article.]
