Table 2. Competitive Repopulating Capacity of IL-31 R -/- and Control (+/+) Bone Marrow Hematopoietic Stem Cells in Lethally Irradiated Recipients.
Percent Chimerism | ||||
---|---|---|---|---|
1 Month | 2 Months | 4 Months | 6 Months | |
+/+ | 60±8 | 67±9 | 70±10 | 70±12 |
IL-31 R -/- | 59±9 | 61±14 | 61±20 | 60±24 |
Mononuclear bone marrow cells from +/+ and IL-31 R -/- mice (both C45.2+) were competed against an equal number of congenic B6/BoyJ (CD45.1+) mononuclear bone marrow cells and injected into lethally irradiated B6.BoyJ mice. Percent CD45.2 chimerism was assessed at 1, 2, 4, and 6 months post transplantation. Results, shown as mean ± 1SD, are based on cells from 3 donors in each group, with each donor collection transplanted into 5 lethally irradiated recipients.