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. Author manuscript; available in PMC: 2009 Dec 25.

Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):8019–8026. doi: 10.1021/jm8011867

Absorption spectral changes on the anaerobic reduction of MAO-A with a stoichiometric amount of p-trifluoromethylbenzylamine followed by the anaerobic addition of 10-fold excess mofegiline (which does not result in any observed spectral changes). Exposure of the sample to oxygen shows re-oxidation of the flavin with minor changes in 300–350 nm region of the spectrum. Absorption spectra of: Oxidized MAO-B (), Reduced MAO-B (), After the anaerobic addition of mofegiline (), After exposure of the sample to O₂ (). The buffer used in this experiment is identical with that described in the legend to Figure 2.

Inline graphic — Absorption spectral changes on the anaerobic reduction of MAO-A with a stoichiometric amount of p-trifluoromethylbenzylamine followed by the anaerobic addition of 10-fold excess mofegiline (which does not result in any observed spectral changes). Exposure of the sample to oxygen shows re-oxidation of the flavin with minor changes in 300–350 nm region of the spectrum. Absorption spectra of: Oxidized MAO-B (), Reduced MAO-B (), After the anaerobic addition of mofegiline (), After exposure of the sample to O₂ (). The buffer used in this experiment is identical with that described in the legend to Figure 2.