Table 2.
Pre-clinical data on combination cancer therapy with CD40 agonists
| Anti-CD40 agonist and… | Rationale | References |
|---|---|---|
| Chemotherapy | Induce tumor death while stimulating immune system | Nowak et al. Can Res, 2003 |
| Radiation | Induce tumor death while stimulating immune system | Honeychurch et al., Blood, 2003 |
| Cancer vaccine | Reverse T cell tolerance Substitute for T cell help |
Sotomayor et al. Nat Med, 1999 Diehl et Al., Nat Med, 1999 |
| Blocking anti-CTLA-4 mAb | Inhibit negative immune regulation while triggering immune activation | Ito et al., JI, 2000 |
| TLR agonists | Synergistic activation of both innate and acquired immunity | Ahonen et al., JEM, 2004 |
| DR5 and CD137 agonist mAb | Induce apoptosis while fully stimulating immune system | Uno et al., Nat Med, 2006 |