Skip to main content
. Author manuscript; available in PMC: 2009 Jul 7.
Published in final edited form as: Mol Pharmacol. 2008 Jan 31;73(5):1381–1393. doi: 10.1124/mol.107.044230

Figure 10. Lovastatin treatment increases serum neurotrophic factors in recovering EAE animals via depletion of geranylgeranyl-PP without lowering cholesterol.

Figure 10

Serum samples of treated/untreated recovering EAE animals with aforementioned agents were collected for determination of neurotrophic factors i.e., PDGF-αβ and IGF-1 using ELISA-based kits. Plot depicts serum level of PDGF-αβ (A) and IFG-1 (B) in EAE animals. Plots depict the level of total cholesterol in the serum samples (C) and SC tissues (D) of treated/untreated EAE animals. Results in plots are expressed as average n = 3/group in three identical experiments. Statistical significance are shown as * p<0.05, *** p<0.001 and NS (non-significant) versus vehicle treated EAE animals and # p< 0.05 versus EAE-Peak.