Figure 5.

The percentage of abnormal estrous cycles in female pups in the F₁ through F₄ generations of the genistein (5A) and EE₂ (5B) multigenerational reproductive studies. Vaginal smears were taken and examined for 14 consecutive days starting 3 days after vaginal opening was observed. Abnormal cycles were defined as 3 or more consecutive days of estrus or 4 or more consecutive days of diestrus. Asterisks above the control group bar indicate a significant overall Kruskal-Wallis’ test for the generation. Asterisks above the dosed group bars indicate a significant difference between the means of the marked group and the control group in that generation (Holm’s-adjusted Wilcoxon’s test). **, p ≤0.01; ***, p ≤0.001