Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Neurotropism as a cause for characteristic PrPSc accumulation patterns. In our model neurotropism is attributed to a local difference in the PrPSc replication rate, k. The initial infection sites are clearly visible in the T1 frames. Because of the higher value of k in the neurons in the rear part of the spatial model, PrPSc deposition is increased in that region whereas comparatively little PrPSc accumulates in the front half.
