Table 2.

MAP kinase inhibitors and their effect in various models of tissue injury

Pathway	Inhibitor	Effect	Reference
ERK1/2	PD98059	↓ CSE induced MMP-1 (in vitro)	Mercer et al 2004
		↓ LPS-induced neutrophilia, cell death, airway leakage	Lee et al 2004
		↓ Airway epithelial thickening	Tamaoki et al 2004
	CI-1040	↓ Adenoma proliferation ←→ Apoptosis	Kramer et al 2004
	UO126	↓ Lung inflammation	Chialda et al 2005
p38	SB230580	↓ LPS-induced MIP2, TNFα, neutrophilia	Arcaroli et al 2004
	SB239063	↓ LPS-induced IL-6 expression (in vitro)	Underwood et al 2000
		↓ LPS-induced fibrosis, MMP-9 expression, neutrophilia	Underwood et al 2000
SAPK/JNK	SP600125	↓ Lung inflammation	Chialda et al 2005
		↓ Arthritic joint swelling, collagenase expression	Han et al 2001
	CEP-1347	↓ Neuronal apoptosis	Maroney et al 1998
		↓ Pancreatic edema, inflammation	Wagner et al 2000