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. 2009 May 3;18(15):2748–2760. doi: 10.1093/hmg/ddp210

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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Figure 5. — Assessment of hearing impairment in Clrn1^−/− mice at P21. ABR: (A) shows that the mean ABR thresholds Clrn1^−/− mice are significantly elevated compared with Clrn1^+/+ mice at 8, 16 and 32 kHz. (B) shows significant delay in latency of peaks 1–4 in Clrn1^−/− mice compared with Clrn1^+/+ mice at 8, 16 and 32 kHz. DPOAE: Assessment of OHC functions in Clrn1^−/− mice. (C and D) Represent input/output (I/O) function test: the input at F1 (x-axis) plotted against the output, represented as mean (and mean ± SD) DPOAE levels (y-axis), at two pairs of frequency: 16–13.3 and 8–6.6 kHz. For I/O test, data were averaged from five Clrn1^+/+ and five Clrn1^−/− mice; results were compared with noise floor average from five trials (n = 5).