. 2003 Feb 17;7(3):R1–R6. doi: 10.1186/cc1887

Table 1.

Pharmacokinetic parameter estimates and precentage coefficients of variation obtained from the blood concentration–time data

		Estimated parameters						Derived parameters (assuming an ingested dose of 1000 mg mercuric sulphate) ingested dose of 1000 mg mercuric sulphate)

Data set		C₁^a(μg/l)	λ ₁^a(/h)	C₂^a(μg/l)	λ ₂^a(/h)	C₃^a(μg/l)	λ ₃^a(/h)	Clearance (l/h)	Vss^bx(l)	λ₁t1/2^c(h)	λ₂t1/2^c(h)	λ₃t1/2^d(h)
All data	Parameter estimate	15.2	0.105	3.18	0.0121	0.273	0.0016	1.74	381	6.60	57.2	425
	% cve^e	25	28	14	15	47	51.3	9.14	37.5	28.5	15.3	51.2
Data minus first point	Parameter estimate			3.66	0.0139	0.318	0.0019	2.33	572		50.0	362
	% cv^e			10.2	10.7	32.3	32.4	4.98	23.1		10.6	32.3

^aConcentration at t hours after dose (see Eqn 1 in text); C₁, C₂and C₃are the coefficients associated with the i^thexponent and λ₁, λ₂and λ₃represent the distribution and elimination rate constants. ^bVss is the volume of distribution at steady state. ^cDistribution half-lives. ^dElimination half-life. ^ePercentage coefficient of variation of the parameter estimate.