Table 1.
Estimated parameters | Derived parameters (assuming an ingested dose of 1000 mg mercuric sulphate) ingested dose of 1000 mg mercuric sulphate) | |||||||||||
Data set | C1a (μg/l) | λ 1a (/h) | C2a (μg/l) | λ 2a (/h) | C3a (μg/l) | λ 3a (/h) | Clearance (l/h) | Vssb x(l) | λ1 t1/2c (h) | λ2 t1/2c (h) | λ3 t1/2d (h) | |
All data | Parameter estimate | 15.2 | 0.105 | 3.18 | 0.0121 | 0.273 | 0.0016 | 1.74 | 381 | 6.60 | 57.2 | 425 |
% cvee | 25 | 28 | 14 | 15 | 47 | 51.3 | 9.14 | 37.5 | 28.5 | 15.3 | 51.2 | |
Data minus first point | Parameter estimate | 3.66 | 0.0139 | 0.318 | 0.0019 | 2.33 | 572 | 50.0 | 362 | |||
% cve | 10.2 | 10.7 | 32.3 | 32.4 | 4.98 | 23.1 | 10.6 | 32.3 |
a Concentration at t hours after dose (see Eqn 1 in text); C1, C2 and C3 are the coefficients associated with the ith exponent and λ1, λ2 and λ3 represent the distribution and elimination rate constants. bVss is the volume of distribution at steady state. cDistribution half-lives. dElimination half-life. ePercentage coefficient of variation of the parameter estimate.