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. 2000 Sep 12;97(19):10584–10589. doi: 10.1073/pnas.97.19.10584

Figure 5.

Figure 5

(A–C) Acute nociceptive tests. (A) AG was inactive in the tail flick (10-min pretreatment) and SP (coadministered) behavioral tests. AG inhibited NMDA behaviors (ED50: 30 nmol, 18–50). (B) NMDA hyperalgesia and nociceptive behavior. AG inhibited NMDA hyperalgesia with greater potency (ED50: 0.45 nmol, 0.089–2.2) than inhibition of NMDA behavior in the same animals (ED50: 53 nmol, 25–112). (C) NMDA-evoked firing. Iontophoretically applied AG inhibited NMDA-evoked firing in 7 of 20 NMDA-responsive dorsal horn neurons tested.