Table 1.
Dendrimer generation (G) | Terminal amines (#) | Naked PAMAM molecular weight # (kDa) | Gd-PAMAM dendrimer molecular weight (kDa) | Gd-DTPA conjugation (%) | Molar relaxivity&(1/mM*s) |
G5 | 128 | 29 | 79† | 52 | 9.81 |
G6 | 256 | 58 | 138† | 45 | 10.04 |
G7 | 512 | 116 | 283‡ | 43 | 9.82 |
G8 | 1024 | 233 | 490‡ | 36 | 10.05 |
#molecular weight obtained from Dendritech, Inc.
†molecular weight measured by MALDI TOF MS
‡mean molecular weight measured by ADF STEM and EFTEM
&molar relaxivity of Gd-DTPA measured to be 4.13 1/mM*s