Table 3.
The association of functional disability with subcortical measure of neurodegeneration.
| Unadjusted Odds Ratio (95% CI) | Adjusted Odds Ratio (95% CI)† | |||||||
| Mild | Severe | Mild | Severe | |||||
| Sex | ||||||||
| Men | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| Women | 2.3 | (0.9–5.4) | 1.9 | (0.9–4.1) | 3.4 | (0.9–12.9) | 1.4 | (0.5–4.2) |
| Age at death | ||||||||
| <75 | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| 75–84 | 1.3 | (0.4–4.1) | 0.7 | (0.2–1.9) | 1.2 | (0.2–7.0) | 0.3 | (0.1–1.4) |
| >84 | 3.3 | (1.0–10.9) | 4.2 | (1.5–12.1) | 2.9 | (0.5–16.2) | 2.4 | (1.0–9.2) |
| Overall effect* | 1.7 | (1.0–3.0) | 2.3 | (1.4–3.8) | 1.6 | (0.7–3.5) | 1.7 | (0.9–3.2) |
| SUBCORTICAL PATHOLOGY (Factor present reference absence) | ||||||||
| NFT | 2.1 | (0.8–5.0) | 1.6 | (0.8–3.6) | ||||
| Neuronal loss | 1.3 | (0.5–3.2) | 3.0 | (1.3–6.6) | 1.4 | (0.3–5.4) | 3.9 | (1.2–12.5) |
| Plaques | 0.6 | (0.1–2.2) | 0.3 | (0.1–1.2) | ||||
| Vascular disease | 2.2 | (0.2–24.9) | 3.3 | (0.4–29.1) | ||||
| Lewy bodies | 8.3 | (0.9–78.3) | 1.8 | (0.2–18.6) | 8.1 | (0.8–87.2) | 1.2 | (0.1–14.2) |
| LB in Substantia nigra | Impossible to calculate; 100% predictive | |||||||
*χ2 test for trend † Adjusted for all other effects in the table.